THE "CAPS" REGISTRY-3

Table 3. Thrombotic clinical manifestations of patients at the time of catastrophic APS.

PATIENT No.	CEREBRAL			RENAL			SKIN
	CLINICAL	IMAGING	BIOPSY	CLINICAL	IMAGING	BIOPSY	CLINICAL	IMAGING	BIOPSY
1	CVA			Failure		Intrarterial thrombosis	LR, ulcers, necrosis	Digital thrombosis
2	Seizure CVA	Infarct		Failure			LR, ulcers		Microthrombi
3	encephalopathy Seizures	Microinfarcts		Failure		GN IV Microthrombi	LR		Microthrombi
4	encephalopathy			Failure		Ischemia
5 (1^st)	TIA					Microinfarcts	LR		Thrombosis
5 (2^nd)			Microthrombi			Microthrombi
6
7	CVA	Infarct		Failure Hypertension	Renal arteries stenosis	GN IV Microthrombi
8	encephalopathy		Microthrombi	Failure			LR, ulcers, cyanosis
9				Failure		Microthrombi	LR
10	encephalopathy			Hematuria Hypertension	infartion
11				Yes			Necrosis
12				Failure Hypertension		Cortical infarction	SH Ulcers		Microthrombi
13	Coma		Multiple infarcts	Failure			Cyanosis Digital ischemia		Microthrombi
14	encephalopathy						Digital ischemia
15				Failure	Low perfusion
16			Microinfarct			Microthrombi
17		Infarcts		Yes
18	encepahlopathy		Microinfarct	Failure			LR Purpura
19						Large infarct
20						Microthrombi
21 (1st)	Encephalopathy Seizures	Microinfarcts		Failure
(2^nd)	Encephalopathy	Microinfartcs
22	Encephalopathy	Infarct	Microinfarct	Failure			Bullous lesions		Microthrombi
23	CVA	Infarct Subdural Hematoma	¿vasculitis?			¿vasculitis?
24	Seizures		Microinfarcts	Failure		GN II Microthrombi
25				Yes
26	CVA	infarct
27
28				Failure		Arterie thromosis
29				Yes
30				Failure	Arterie thrombosis	Arterie thrombosis
31	Encephalopathy			Failure Hypertension
32	Headache	Venous sinus Thrombosis					Purpura Digital ischemia
33	Encephalopathy			Failure			Gangrene
34	Encephalopathy	Multiple infarcts		Failure Hematuria			LR Ulcers		Microthrombi
35	Encephalopatthy	Multiple infarcts		Failure			LR
36				Failure		Crescenti GN
37		Infarcts		Yes			LR
38				Yes			Gangrene
39		Infarcts		Yes			LR
40			Infarcts	Failure Hypertension		Microthrombi Fragmented erythrocytes	LR
41	Encephalopathy Seizures			Failure
42		Infarcts
43		Infarcts
44
45
46				Proteinuria			Digital ischemia
47	Encephalopathy Headache	Multiple infarcts	Microthrombi				LR Cyanosis
48				Failure Hypertension		GN IV Microthrombi	Multiple hematomas
49	CVA Seizures	Infarct		Failure
50	Diplopia Hemibalism Vertgo		Multiple infarcts	Failure Proteinuria Hypertension	Multiple infarcts		Ulcers
51	Headache						Rash		Microthrombi
52				Failure		Microthrombi	Purpura Rash
53	Encepahlopathy		Microthrombi			Microthrombi	Digital ischemia Raynaud		Microthrombi
54	Encephalopathy CVA		Microthrombs	Failure		Microthrombi	LR Ulcers		Microthrombi
55							LR, Purpura Ulcers Necrosis		Microthrombi
56							Raynaud
57				Failure			Gangrene		microthrombi
58	CVA Encephalopathy	Multiple infarcts		Failure		GN IV Microthrombi
59	Encephalopathy						LR
60
61	Encephalopathy	Cerebellar infarcts		Failure Hypertension			LR Ulcers		Microthrombi
62
63	Encepahlopathy	Infarcts		Failure			LR, ulcers, gangrene		Microthrombi
64	CVA	Multiple infarcts		Failure			SH, LR ulcers
65		Venous oclussion
66							LR, ulcers, gangrene		Microthrombi
67
68	Encephalopathy	Multiple infarcts	Microthrombi	Failure			Raynaud Ulcers
69						Microthrombi	Purpura
70(1st)	Encephalopathy Headache	Infarct
(2nd)		Microinfarct		Failure Hypertension			LR, Purpura Ulcers
(3rd)				Failure Hypertension			Ulcers
71				Failure Hypertension	Infarcts
72	Encephalopathy	Intracerebral hemorrhage		Failure	Perfusion defects	GN IV Microthrombi	LR Cyanosis
73							LR Purpura Gangrene		Microthrombi
74	Encephalopathy	Microinfarcts					LR
75	Encephalopathy	Microinfarcts		Yes			LR
76	CVA	Infarcts		Yes			LR, ulcers
77	CVA	Infarcts					LR
78	CVA	Infarcts		Yes			LR
79	Encephalopathy Seizures	Microinfarcts		Yes
80	Encephalopathy	Microinfarcts		Yes			Ulcers
81	Encephalopathy	Microinfarcts		Yes			Ulcers
82	Encephalopathy			Proteinuria			Ulcers
83(1st)	Encephalopathy	Microinfarcts		Failure Proteinuria	Vein thrombi
83(2nd)	Encephalopathy	Chronic subdural hematoma		Failure Proteinuria	Vein thrombi
84	TIA (2)			Failure Proteinuria	Infarcts		LR		Microthrombi
85				Failure Proteinuria		Crescentic GN Microthrombi
86		Infarcts Sinus thrombi		Failure Proteinuria		Microthrombi	Ulcers
87	Encephalopathy	Microinfarcts		Failure		Microthrombi	Petechiae
88	CVA	Infarcts				Infarct	SH
89		Venous thrombi		Failure			Gangrene
90							Gangrene		Microthrombi
91						Microthrombi
92	Encephalopathy		Microinfarcts	Failure		Microthrombi	Urticaria		Microthrombi
93	Seizures		Microinfarcts	Failure		GN IV Microthrombi			Microthrombi
94			Microinfarcts	Proteinuria Hypertension		GN IV Microthrombi	LR		Microthrombi
95				Failure		Microthrombi
96	CVA Encephaopathy	Multiple infarcts	Microthrombi		Multiple infarcts	Microthrombi
97	Encephalopathy Seizures	Microinfarcts
98	CVA	Infarct
99		Multiple infarcts. Haemorrhage		Failure			Purpura
100							Ecchymoses
101							Raynaud Gangrene
102	Encephalopathy			Failure		Microthrombi
103				Failure
104	Seizures			Failure	Venous thrombi
105				Failure Hypertension			Echymosis
106	CVA			Failure Proteinuria
107	Encephalopathy CVA		Microthrombi	Faiñure		Microthrombi	Ulcers		Microthrombi
108	Encephalopathy Seizures			Failure			Gangrene
109	Seizures	Multiple infarcts		Failure			Purpura
110	Seizures	Multiple infarcts		Failure Proteinuria Hypertension		Microthrombi
111				Failure
112				Failure			LR
113				Failure	Infarct
114				Failure Hypertension			petechiae
115			Infarct	Hematuria Proteinuria		microthrombi
116
117		Lacunar infarct		Hematuria Hypertension	Artery thrombi
118		Infarcts
119					Artery thrombi
120
121
122	Encephalopathy			Failure			Digital necrosis
123	Coma			Failure
124				Failure Proteinuria Hypertension			LR, SH Purpura		Vasculitis Microthrombi
125	Encephalopathy CVA	Multiples infarcts		Failure Proteinuria			LR Necrosis
126	CVA			Yes			Ecchymoses LR
127	CVA			Yes			LR Ulcers
128							LR
129	CVA (2) simultaneous in differents areas
130	CVA						LR, Ulcers Digital necrosis
131						Multiple infarcts
132	Encephalopathy	Microinfarcts		Failure			Ulcers
133	CVA Encephalopathy	Infarcts		Failure Proteinuria			Petechiae
134	CVA Seizures			Failure	Thrombi
135				Failure
136			Microthrombi	Failure		GN IIA Microthrombi			Microthrombi
137
138				Failure Proteinuria Hypertension		Microthrombi	Digital ischemia
139	CVA			Failure			LR, digital ischemia
140				Failure