EUROPEAN FORUM ON ANTIPHOSPHOLIPID ANTIBODIES

MULTICENTRE STUDIES

FAMILIAL ANTIPHOSPHOLIPID SYNDROME

Genetic study on Familial Antiphospholipid Syndrome.

Coordinators: JC Piette, M Michel, O Meyer, A Tincani, R Cervera, Y Shoenfeld, E Tournier-Lasserve, MC Boffa

Antiphospholipid syndrome (APS) is familial in 10% of cases. The genetic factors associated with the production of aPL are currently poorly known, though several studies have pointed out a possible role of the MHC region or B2GPI polymorphism. The development of thrombosis may be associated with the presence of concomitant genetic thrombophilic factors (Factor V Leiden, PAI-1 4G/5G polymorphism...).

The AIM of the study is to identify the genetic basis of familial APS.

Patients: 

- familial (n>2) APS: Diagnosis of APS is based on International Consensus Criteria (Arthritis Rheum 1999; 42: 1309-1311). Patients may have, or not, the primary form of APS (i.e. patients with SLE-APS or Lupus-like APS are OK for study)

- familial (n>4) asymptomatic aPL (LA/VDRL)

For additional information and applications, please e-mail:

jcpiette@free.fr